SLU-PP-332 (Sloop) at a Glance

What Is SLU-PP-332?

SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptors (ERRα, ERRβ and ERRγ) developed at Saint Louis University. Despite the “Sloop” nickname and frequent mislabeling as a “peptide” in retail listings, SLU-PP-332 is not a peptide — it is a non-peptidic small molecule designed to activate orphan nuclear receptors that regulate mitochondrial biogenesis and oxidative metabolism. It is supplied strictly as a research-use-only laboratory compound.

SLU-PP-332 was first characterized in a 2023 study by Billon et al. in ACS Chemical Biology, where the Burris laboratory reported it as a pan-ERR agonist with an EC₅₀ of approximately 98 nM at ERRα, 230 nM at ERRβ and 430 nM at ERRγ, and demonstrated that it induces an acute aerobic-exercise gene program in skeletal muscle of mice. Follow-up work by Banerjee et al. showed that chronic dosing in obese mouse models reduced fat mass, improved glucose tolerance and increased energy expenditure without changes to food intake.

Because of this profile, SLU-PP-332 has become a widely cited reference tool in the “exercise mimetic” class of preclinical compounds and is in active demand by researchers studying mitochondrial function, fatty-acid oxidation, type IIa fiber adaptation and metabolic-syndrome models. Background reference: SLU-PP-332 (Wikipedia).

How SLU-PP-332 Works ERR Activation & Mitochondrial Biogenesis

The ERR family of nuclear receptors

Estrogen-related receptors (ERRα, ERRβ, ERRγ) are orphan nuclear receptors — transcription factors highly expressed in energy-demanding tissues (skeletal muscle, heart, brown adipose, liver). They do not bind estrogen; despite the name, they regulate independent gene programs that control mitochondrial biogenesis, oxidative phosphorylation, fatty-acid β-oxidation and the TCA cycle.

Pan-ERR agonism by SLU-PP-332

SLU-PP-332 binds the ligand-binding domain of all three ERR isoforms with strongest activity at ERRα. Activation drives recruitment of the master transcriptional coactivator PGC-1α, which then upregulates the gene networks responsible for building new mitochondria and increasing oxidative capacity in muscle and other metabolic tissues. In the published in-vivo work, this manifested as a shift toward type IIa oxidative muscle fibers and enhanced treadmill endurance in mice.

Why it is called an “exercise mimetic”

Endurance exercise activates the same ERR/PGC-1α transcriptional axis. SLU-PP-332 reproduces large parts of that gene-expression signature pharmacologically, in sedentary research animals, which is why the published literature consistently characterizes it as an exercise-mimetic chemical tool for preclinical metabolic research. See Billon et al. 2023, ACS Chem Biol on PubMed.

Published Research Findings on SLU-PP-332

Billon et al. 2023 — ACS Chemical Biology

Identified SLU-PP-332 as a pan-ERR agonist with EC₅₀ of 98 / 230 / 430 nM (ERRα/β/γ), confirmed in-vivo plasma and muscle exposure after intraperitoneal dosing, and showed enhanced exercise endurance and an ERRα-dependent acute aerobic gene program in skeletal muscle of mice.

Banerjee et al. 2024 — Journal of Pharmacology and Experimental Therapeutics

Reported that SLU-PP-332 administered to diet-induced obese (DIO) and ob/ob mice produced reduced fat mass, improved glucose tolerance, increased energy expenditure and elevated fatty-acid oxidation, mirroring metabolic adaptations typically associated with sustained aerobic training. Open-access PMC version.

Wang et al. 2023 — American Journal of Pathology

Showed that ERR agonism by SLU-PP-332 reversed mitochondrial dysfunction and inflammation in aging-kidney models, broadening the receptor’s research relevance beyond skeletal muscle.

Important context

All published efficacy and safety data on SLU-PP-332 to date are from cell-based and rodent studies. There are no completed human clinical trials, no human pharmacokinetic data and no FDA-approved indication. SLU-PP-332 is supplied by Sourcetides strictly for in-vitro and preclinical research, and is not for human or veterinary use.

SLU-PP-332 Specifications & Third-Party Testing

Why Buy SLU-PP-332 from Sourcetides

• 99%+ verified purity — every batch independently tested by HPLC and mass spectrometry, never assumed.
• Batch-matched COA included — the analytical certificate corresponds to the exact lot you receive, not a generic specimen.
• US-based dispatch — no international customs risk, no surprise seizures, no weeks-long delays that compromise compound integrity.
• Research-grade material only — no “bulk repackaged” chemistry of unverified origin.
• Cold-aware fulfillment — tablets are shipped in protective packaging suitable for stable transit.
• Responsive specialist support — reach the team for COA copies, batch questions, or research documentation requests.

Buy SLU-PP-332 Online in the USA — Shipping, Payment & Ordering

Sourcetides ships SLU-PP-332 across the continental United States with same-day dispatch on orders placed before 12:00 PM EST, Monday through Friday. Orders are tracked end-to-end and supported by US-based customer service. Researchers ordering SLU-PP-332 online from Sourcetides receive:

• Tracked domestic shipping — standard delivery in 2–5 business days
• Tamper-evident packaging that confirms unbroken chain-of-custody
• The corresponding COA referencing the exact batch in your shipment
• Multiple secure checkout options (Visa, MasterCard, PayPal, Stripe)
• Discreet labeling consistent with research-use-only supply standards

Where research timelines are critical, expedited shipping options are available at checkout. International orders are evaluated on a case-by-case basis depending on local research-chemical regulations — contact the Sourcetides team before purchase if you are ordering outside the United States.

To order SLU-PP-332 online today: select your quantity (100, 200 or 500 tablet bottle) at the top of this page, complete checkout, and your batch will be prepared for same-day dispatch.

SLU-PP-332 Compared to Related Research Compounds

Unlike compounds that act through energy-stress sensing (AICAR) or fatty-acid receptor pathways (Cardarine), SLU-PP-332 directly engages nuclear-receptor transcription, giving researchers a precise tool for ERR-specific mitochondrial-biogenesis studies that other small molecules in the metabolic-research class cannot replicate.

SLU-PP-332 Storage, Stability & Handling

• Unopened bottle: store in a cool, dry, dark location below 25°C. Do not freeze tablets.
• After opening: reseal the bottle immediately and refrigerate (2–8°C) to maximize stability of remaining tablets.
• Avoid: direct sunlight, humidity, repeated temperature swings, or storage in vehicles/garages.
• Shelf life: SLU-PP-332 in solid form is generally stable for 12–24 months under recommended conditions. Refer to the COA included with your batch for the lot-specific expiration date.
• Handling: use clean gloves and avoid skin contact during laboratory handling. Dispose of unused material in accordance with institutional and local hazardous-chemical regulations.

SLU-PP-332 Compliance and Research Use Only

SLU-PP-332 sold by Sourcetides is supplied For Research Use Only (RUO). It has not been evaluated by the U.S. Food and Drug Administration (FDA) and is not intended for human consumption, veterinary use, diagnosis, treatment, prevention or cure of any disease or condition. Purchasers must be qualified researchers or operate within an institutional research setting and agree to use the compound exclusively for in-vitro or preclinical investigation in compliance with all applicable federal, state and local laws, including the Federal Food, Drug, and Cosmetic Act. Misuse is strictly prohibited and is solely the responsibility of the purchaser. Buyers must be 21 years of age or older.

SLU-PP-332 Frequently Asked Questions

Is SLU-PP-332 a peptide?

No. SLU-PP-332 is a synthetic small-molecule ERR pan-agonist developed from the GSK4716 scaffold. It is frequently mis-labeled as a peptide in retail listings, but it has no amino-acid sequence and behaves chemically as a non-peptidic nuclear-receptor ligand.

What does SLU-PP-332 do mechanistically?

It binds and activates ERRα, ERRβ and ERRγ with the strongest potency at ERRα. Activation recruits the coactivator PGC-1α and upregulates gene networks for mitochondrial biogenesis, oxidative phosphorylation, the TCA cycle and fatty-acid β-oxidation in research models.

Why is SLU-PP-332 nicknamed “Sloop”?

“Sloop” is an informal community shorthand derived from “SLU-PP” (Saint Louis University — the lab where it was developed). It refers to the same compound as SLU-PP-332.

What is the purity of Sourcetides SLU-PP-332?

Sourcetides supplies SLU-PP-332 at a verified purity of 99% or higher, confirmed by independent HPLC analysis and mass spectrometry on every batch, with the corresponding Certificate of Analysis included.

Where can I buy SLU-PP-332 online in the USA?

You can buy SLU-PP-332 online in the USA directly from Sourcetides on this product page. Orders placed before 12:00 PM EST ship the same business day from the United States. Select a quantity at the top of the page and complete checkout to order.

How is SLU-PP-332 shipped?

Tracked domestic delivery with same-day dispatch on US orders placed before 12:00 PM EST, Monday through Friday. Standard transit is 2–5 business days; expedited options are available at checkout.

Has SLU-PP-332 been tested in humans?

No. All published efficacy and safety data are from cell-based assays and rodent studies. There are no completed human clinical trials and no FDA-approved use. SLU-PP-332 is supplied strictly for in-vitro and preclinical research.

How should SLU-PP-332 tablets be stored?

Sealed bottles should be kept in a cool, dry, dark location below 25°C. After opening, refrigerate at 2–8°C and reseal between uses. Do not freeze and avoid direct light or humidity.

How does SLU-PP-332 differ from Cardarine (GW501516)?

Cardarine activates PPARδ, a nuclear receptor that drives fatty-acid oxidation through a different transcriptional axis. SLU-PP-332 activates the ERR family and works primarily through PGC-1α-mediated mitochondrial biogenesis. Both are studied as exercise-mimetic compounds but engage distinct pathways.

Does Sourcetides ship SLU-PP-332 internationally?

SLU-PP-332 international shipping is reviewed on a case-by-case basis depending on the destination country’s research-chemical regulations. Contact the Sourcetides team before placing an international order to confirm eligibility and transit options.

What payment methods are accepted?

Sourcetides accepts Visa, MasterCard, PayPal and Stripe-processed cards. Payment is processed securely at checkout; payment details are never shared with third parties beyond the card network and processor.

Will I receive a Certificate of Analysis (COA)?

Yes. Every Sourcetides SLU-PP-332 order includes a batch-specific COA referencing the exact production lot in your shipment, with HPLC purity data and mass-spectrometric identity confirmation.

Order SLU-PP-332 — Trusted USA Research Supplier

Sourcetides supplies high-purity SLU-PP-332 (Sloop) for laboratory and preclinical research with the documentation, dispatch speed and analytical transparency serious researchers expect. Choose your quantity above and complete checkout to receive your batch with same-day US dispatch.